WebJan 1, 2024 · PDF On Jan 1, 2024, Chau Thi Ngoc Dieu and others published Anaphylaxis to Cisplatin after Carboplatin Hypersensitivity Reaction in Advanced Non-Small Cell Lung Cancer Find, read and cite all ... WebFeb 15, 2024 · Carboplatin-, oxaliplatin-, and cisplatin-specific IgE: cross-reactivity and value in the diagnosis of carboplatin and oxaliplatin allergy. J Allergy Clin Immunol Pract. 2013; 1 : 494-500 View in Article
Hypersensitivity and cross-reactivity to cisplatin and …
WebThe kinetics of the aquation reactions of cisplatin and carboplatin and their subsequent reactions with DNA, both in vitro and in vivo, have been measured. The results have been extrapolated to indicate the expected cytotoxicity of these compounds in cells obtained from human cancer patients. WebSep 9, 2014 · Cisplatin undergoes hydrolysis within the cell producing a highly reactive charged platinum complex [Pt(NH3)2ClH2O]+. After further hydrolysis, this complex binds to DNA bases through the N7 atom (preferably guanine). This DNA cross-linkage mechanism interferes with cell division and replication. how many students at centennial high school
Cisplatin in cancer therapy: molecular mechanisms of action
WebApr 15, 2024 · The treatment was well tolerated only he developed grade 2 mucositis and weight loss associated with cisplatin [ duration of treatment to reactions onset not … WebJul 1, 2016 · HSRs to cisplatin and carboplatin can be potentially life-threatening. The symptoms can range from a mild rash to severe anaphylaxis. Doctors should be aware of these reactions, determine appropriate treatment, and know the cross-reactivity among these drugs. Keywords Cisplatin Carboplatin Cross-reactivity cancer Anaphylaxis … WebFor carboplatin and cisplatin, the first hypersensitivity reaction typically occurs around the second and third re-exposure during the second line of therapy (eighth and ninth courses overall). For oxaliplatin, the first hypersensitivity reaction can occur throughout the treatment course. how many students at capella university