WebAug 5, 2011 · HMG CoA reductase inhibitors (statins) are prone to interaction with antiretrovirals as a result of metabolism through CYP3A4 and CYP2C19 and inhibition of hepatic uptake by the OATP1B1 transporter [2,109]. Protease inhibitors can induce dyslipidemia or augment existing dyslipidemia, resulting in the need for antilipidemic … WebMay 31, 2024 · Simvastatin belongs to the drug class known as HMG-CoA reductase inhibitors, also called statins. A class of drugs is a group of medications that work in a similar way. ... Strong CYP3A4 ...
Rhabdomyolysis reports show interaction between …
WebCYP3A4 inhibitors with caution. Minor CYP3A4 inhibitors, such as the macrolide antibiotics, azithromycin and roxithromycin, have only a minimal effect on simvastatin and atorvastatin levels. However, there have been isolated case reports of rhabdomyolysis when they have been used in combination with simvastatin.1 CYP3A4 inducers include ... WebSep 1, 2024 · Simvastatin tablets are contraindicated in the following conditions: • Concomitant use of strong CYP3A4 inhibitors (select azole anti-fungals, macrolide antibiotics, anti-viral medications, and … how much money did cyberpunk make
Concomitant use of cytochrome P450 3A4 inhibitors and …
WebJun 16, 2014 · The concurrent use of OATP inhibitors plus separate CYP3A4 inhibitors would produce a similar risk of elevated plasma concentrations. This dual mechanism can result in a very large increase in statin concentrations, as demonstrated by the cyclosporine—simvastatin interaction. Inhibition of OATP may also alter the efficacy of … WebOct 1, 1999 · Simvastatin is a substrate for cytochrome P450 3A4 (CYP3A4). CYP3A4 inhibitors can elevate the plasma concentration of HMG-CoA reductase inhibitory … WebSimvastatin is not an inhibitor of CYP3A4 and is not expected to affect the plasma levels of other drugs metabolized by CYP3A4. Coadministration of simvastatin (40 mg QD for 10 days) resulted in an increase in the maximum mean levels of cardioactive digoxin (given as a single 0.4 mg dose on day 10) by approximately 0.3 ng/mL [see DRUG ... how do i order a marriage certificate