WebThe mechanisms of oxygen sensing and the mechanisms by which hypoxia induces stabilization of the HIF-1α protein are currently unknown. The finding by several investigators of an inhibitory effect of H 2 O 2 on HIF-1 formation and Epo gene expression suggested that redox changes are likely to be involved in oxygen sensing and/or signal … WebHypoxia induces the stabilization and transcriptional activation of the hypoxia-inducible factor 1α (HIF-1α) protein, the regulatory member of the HIF-1 complex. The molecular mechanisms that are responsible for oxygen sensing and the downstream pathways utilized by the hypoxic signal are still poorly understood. One hypothesis for oxygen …
Oxygen Sensing and Hypoxia Signaling SpringerLink
WebIntratumoral hypoxia induces the HIF-1-dependent expression of the chemokine CCL28, which recruits regulatory T cells that promote tumor tolerance as well as angiogenesis . … WebThis study demonstrated that HIF-1α-activated TMEM237 interacted with NPHP1 to activate the Pyk2/ERK pathway, thereby promoting HCC progression. Hypoxia-inducible factors … peter aspinall birkenshaw death
Sensing and Responding to Hypoxia, Molecular and Physiological …
Web5 de set. de 2024 · Overall, >20 non-HIF substrates have been reported for different PHD enzymes 97. Such PHD substrates might transduce other physiological responses to … Web18 de ago. de 2000 · The significance of HIF-1 in transcriptional regulation was recently demonstrated by the marked decrease in mRNA expression of VEGF and glycolytic enzymes seen during hypoxia in HIF-1α- or ARNT-deficient murine embryonic stem cells (10, 11, 12). The mechanism by which HIF-1 activation is initiated during hypoxia … Webmechanisms underlying HIF oxygen sensing.43 The HIF/PHD oxygen-sensing pathway plays a central role in cellular adaptation to hypoxia, regulating biologic processes essential for cell survival. These include glycolysis, mito-chondrial metabolism, angiogenesis, immune responses, and erythropoiesis (Figure 1).10 HIF transcription factors, of peter astbury cntw